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MOTS-c research vial from ZestyRat Research

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VialGLP-1 & Metabolic

MOTS-c

Mitochondrial-derived peptide studied for metabolic regulation and exercise-mimetic signaling. 20mg vial.

For research use only · not for human consumption

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MOTS-c Mitochondrial Peptide
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Independent research on MOTS-c. Our sister publication Peptides Uncaged maintains a plain-English research guide covering mechanism, the published literature, and how vendors are scored on purity and COA transparency. It is written independently of any lab. How to read a COA is worth ten minutes before your first order.
The research

What MOTS-c is being studied for

MOTS-c is a mitochondrial-encoded peptide with 16-aa’s encoded within the 12S rRNA locus of mtDNA in human cells. MOTS-c can translocate into the nucleus in response to metabolic stress and regulation of adaptive nuclear gene expression. This allows the peptide to promote resistance of metabolic stress by upregulating the mitochondrial genome.

Upregulating these genes encourages mitochondrial biogenesis. MOTS-c inhibits the methionine-folate cycle resulting in purine synthesis, increase in PCG-1α (a key regulator of energy metabolism), and AICAR (5- Aminoimidazole-4-carboxamide ribonucleotide) accumulation which activates AMPK (5’- adenosine monophosphate-activated protein kinase).

This acts as an energy sensor by monitoring the ratio of AMP and ATP. AMPK restores homeostasis by initiating catabolic processes for ATP production in case of energy deficits. In addition, literature suggest that MOTS-c decreases insulin resistance and increases GLUT4 uptake in muscle. The peptide is mainly used for weight loss (regulating muscle and fat metabolism) and energy (cell survival in toxic conditions).

MOTS-c is consistently used by sports performance athletes to enhance one’s performance. It also displays a promising effect in longevity. MOTS-C COA.

Summary of published preclinical and clinical literature, provided for research context only. Not a claim of efficacy and not medical advice.

Common questions

MOTS-c — FAQ

What is MOTS-c?

Mitochondrial-derived peptide studied for metabolic regulation and exercise-mimetic signaling. 20mg vial.

What formats does MOTS-c come in?

ZestyRat Research supplies MOTS-c as vial. Available options: 20mg vial vial at $80.

Is there a certificate of analysis for MOTS-c?

Yes. ZestyRat Research is our top-rated research supplier and provides a certificate of analysis on every batch. A COA reports identity by mass spectrometry and purity by HPLC — if you are not sure how to read one, our guide on reading a certificate of analysis walks through it line by line.

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Testing
Independently tested, 99%+ purity, per ZestyRat's own published standard.
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Every compound referenced on this site is sold by its vendor strictly as a research chemical for in-vitro laboratory research only — not for human or animal consumption, and not intended to diagnose, treat, cure or prevent any disease. Nothing here is medical advice. We earn a commission on orders placed through our links, at no additional cost to you; all material connections are disclosed in line with FTC guidelines.

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